What is the difference?

PetrolatumSqualane
What it isPetroleum jelly, an occlusive ingredient that reduces evaporative water lossA stable oil made by converting squalene
FeelThick and greasy as an ointmentLightweight
Best reason to choose itDry, thick, scaly areas that need lasting protectionDry skin when you dislike a thick face cream
Place in a routineA protective layer over a cream on very dry areasAfter lighter products such as serums or toners
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Choose petrolatum for stubborn dry patches where moisture retention matters more than finish. An ointment's greasy feel is a real tradeoff, not a texture the marketing department can rename away. Petroleum jelly is also an inexpensive option that works well for many children with eczema. Choose squalane if you want a lighter facial oil, including when your skin still feels dry after moisturizer.124

A cream can remain the foundation of either routine. Creams and ointments are better choices than lotions for pronounced dryness; a fragrance free cream containing ceramides is particularly useful for people with diabetes. Squalane and squalene are related but different: squalane is the more stable form used in skincare.35

How should you apply them?

  1. 1Wash gently with warm rather than hot water. Use a gentle cleanser instead of a harsh soap or strong body wash.
  2. 2Apply your cream or ointment immediately after bathing. Reapply after swimming and whenever skin feels dry or itchy.
  3. 3For very dry patches, use petrolatum as the protective ointment layer. For dry, cracked heels, a specific bedtime routine is a cream containing 10% to 25% urea, followed by petroleum jelly and white cotton socks.
  4. 4If choosing squalane, apply lighter serums or toners first, then layer the oil on top to help prevent moisture from leaving.
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Neither option is restricted to bedtime. Regular moisturizing two to three times daily can maximize benefits, and very dry skin can benefit from an occlusive moisturizer every couple of hours. A lighter texture can make regular use easier, because a moisturizer left in the cupboard has an excellent finish and no useful job.1

How soon should dryness improve?

Mild dryness can clear within a few days of regular moisturizing. Very dry, inflamed skin can need longer treatment, and eczema sometimes needs medication as well as moisturizer. Dryness involves the skin's outer barrier losing its ability to hold water, not simply a shortage of oil. Keep moisturizing regularly to reduce relapses rather than stopping as soon as the surface feels smoother.6

Who should be careful?

For sensitive skin, check the whole formula rather than choosing by the headline ingredient. Fragrances, preservatives and dyes can trigger reactions. Squalane is an option for acne prone skin, but other oils in a blend can contribute to blocked pores. Occlusive moisturizers can aggravate acne or inflamed hair follicles, so reconsider a heavy ointment if those problems develop.12

For a child with eczema, use a thick cream or ointment at least twice daily. After bathing, gently pat the skin partly dry; apply prescribed skin medicine as directed when the skin is almost dry, then moisturizer over the medicine and elsewhere. Moisturizing supports eczema care rather than replacing a prescribed treatment.4

Stop a moisturizer that causes an allergic skin reaction. Seek dermatology care if dryness remains uncomfortable or skin fails to heal. If you have diabetes, deep cracks carry an infection risk: swelling, discoloration, pain, leaking fluid or a worsening wound need immediate medical attention.13

Where this answer comes from

  1. 1Emollients and Moisturizers (Moisturisers)dermnetnz.org
  2. 2Squalane: What It Is and Benefitshealth.clevelandclinic.org
  3. 3Dermatologist-recommended skin care for people with diabetesaad.org
  4. 4Atopic dermatitis: Self-careaad.org
  5. 5Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblastpmc.ncbi.nlm.nih.gov
  6. 6Moisturizing Different Racial Skin Typespmc.ncbi.nlm.nih.gov