Which should I start first?

There is no single required order. Retinol is an option for mild acne, uneven pigmentation and fine lines. Vitamin C helps brighten skin and supports collagen, the protein that gives skin structure. Choose one based on your main goal rather than starting both to cover every possibility.23

How to introduce them

  1. 1Test the first product on your inner forearm before using it on your face. For a general skincare product test, apply a small amount twice daily for four to five days. Do not proceed if redness, itching or another reaction develops.
  2. 2Introduce only that product. Follow its directions rather than applying extra to speed things up. Keep the rest of your routine unchanged while you check how your skin responds.
  3. 3If you start with retinol, choose the lowest strength you can find. Apply it every other night initially, or once every few days if needed. Increase use gradually as tolerated, following the package directions.
  4. 4Once the first product is tolerated, test and introduce the second separately. Use the same cautious approach instead of increasing both products at once.
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Where do they go in my routine?

Once you have introduced both, use vitamin C in the morning after gentle cleansing, followed by moisturizer and broad spectrum sunscreen of at least SPF 30. Use retinol at night after cleansing and patting your skin dry, followed by moisturizer. For facial retinol, use a thin layer, about a pea sized amount, avoiding your eyes, mouth and nose.24

A thin layer of moisturizer before retinol can help buffer its irritating effects. Avoid doubling up unintentionally: if your serum contains retinol, you probably do not need retinol in your moisturizer too. Choose vitamin C in an opaque container because light can reduce its effectiveness.2

What should I expect?

Visible retinol improvements take several weeks, and changes in fine lines can take months. Dryness, redness and peeling can occur as you adjust. Do not treat burning as evidence that a product is working: stop a nonprescription product that stings, burns or tingles. If a prescribed product causes those sensations, ask your prescriber whether they are expected before stopping it.14

Who should be more cautious?

Do not use retinol or other retinoids during pregnancy. If you are breastfeeding, speak with your healthcare provider before starting retinol. Get advice before introducing a retinoid if you have skin allergies, marked dryness or persistent redness; topical retinoids can also worsen eczema. Irritation can trigger dark marks in darker skin, so slow introduction and moisturizer matter. If you already use a prescription retinoid, ask your prescriber about adding products rather than treating it as an ordinary retinol serum.345

Where this answer comes from

  1. 1How to maximize results from anti-aging skin care productsaad.org
  2. 2Anti-Aging Skin Care: Ingredients and Routinehealth.clevelandclinic.org
  3. 3Retinoid or retinol?aad.org
  4. 4Retinol: Cream, Serum, What It Is, Benefits, How To Usemy.clevelandclinic.org
  5. 5Topical retinoids (vitamin a creams)dermnetnz.org