How often should I use it at first?

A starting schedule of two to three applications per week is an option, rather than going straight to every night. Test a small affected area first, then gradually increase frequency if your skin tolerates treatment. There is no fixed weekly timetable for increasing it. If you already have a prescribed schedule, ask your clinician before changing it.234

Do not apply adapalene more than once daily or use extra to speed things up. More medication does not improve results faster and can increase irritation. If you miss an application, use it when you remember unless the next dose is nearly due; then skip it. Never double the dose.12

How do I apply adapalene?

A gentle cleanser belongs in the routine, even if its packaging has nothing dramatic to announce.5

  1. 1Remove makeup, gently cleanse the affected skin and pat it dry without scrubbing.
  2. 2For cream or gel, use clean fingertips to spread a thin film over the whole area affected by acne, not just individual spots. Follow the specific directions for other formulations.
  3. 3Keep adapalene away from your eyelids, lips, eyes, nose and mouth. Do not apply it to broken, sunburned or eczema affected skin.
  4. 4Wash your hands after application. Let adapalene absorb before applying moisturizer or cosmetics.
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If irritation makes this routine difficult, your dermatologist can adjust the amount or frequency, or recommend moisturizer before the retinoid instead. Moisturizer first is an irritation management option, not a reason to override your own treatment instructions.4

What should I expect?

Adapalene is a retinoid, a medicine related to vitamin A that helps keep pores from becoming blocked. Acne can initially look worse as previously unseen pimples reach the surface. Full benefit can take 8 to 12 weeks or longer, so early breakouts alone are not a reason to abandon treatment.12

Dryness, redness and mild irritation are common early effects and tend to improve after two to four weeks. If your skin becomes very irritated, reduce frequency or pause treatment. Stop and contact your doctor if irritation is severe or does not improve. Report burning, itching, crusting or peeling promptly rather than treating these as something to push through.26

What else belongs in the routine?

Avoid adding other acne products to the same areas unless your care team has told you to use both. Other retinoids, exfoliating acids such as salicylic or glycolic acid, abrasive cleansers and strongly drying products can add irritation.256

Protect exposed skin with a water resistant, broad spectrum sunscreen of SPF 30 or higher, alongside shade and protective clothing. Follow a higher SPF instruction if your clinician gives one. Avoid tanning beds and sunlamps, and do not use hot wax on treated areas.146

When should I get medical advice?

Discuss pregnancy plans and breastfeeding before using adapalene. Stop treatment and contact your doctor if you think you are pregnant. Tell your clinician about eczema, sensitive skin, previous reactions and other medicines before starting.126

Seek urgent medical help for difficulty breathing or swelling of the face, lips, tongue or throat. Arrange a medical review if acne is not improving with self treatment, is deep or painful, causes scars, or affects your mental health.17

Where this answer comes from

  1. 1Adapalene: MedlinePlus Drug Informationmedlineplus.gov
  2. 2Adapalene Gels and Cream – Differin and Epiduodchft.nhs.uk
  3. 3Acnebad.org.uk
  4. 4Acne: Diagnosis and treatmentaad.org
  5. 5Acnenhs.uk
  6. 6Adapalene Acne Treatment: Uses & Side Effectsmy.clevelandclinic.org
  7. 7Acnenhs.uk