How often should I use Differin when starting?

How do I build up to daily use?

First try Differin on a small test area. For a gentle introduction, use it on two or three separate evenings each week. Increase the frequency gradually if your skin tolerates the current schedule; there is no fixed weekly timetable you need to complete. If irritation develops, use it less often rather than pushing toward nightly use.1

This starting approach applies to Differin 0.1% adapalene cream or gel; the US Differin Gel directions specify once daily, morning or evening. Follow your prescriber's instructions if you have been given a different schedule. Never apply more than once daily, and do not double a dose to make up for one you missed.123

How should I apply Differin?

A starting routine needs a gentle cleanser, Differin and moisturizer, not a supporting cast large enough to need credits.2

1. 1Remove makeup and gently wash with a mild cleanser. Pat dry rather than scrubbing.
2. 2Apply to dry skin. If acne medicines irritate your skin, waiting 10 to 15 minutes after washing is a general option.
3. 3For US Differin Gel, spread a pea sized amount in a thin layer over the full face. Avoid the eyes, lips and nose.
4. 4Follow with moisturizer once Differin has been absorbed. Wash your hands after applying.

Differin treats the whole acne prone area rather than individual spots, so it is not a tiny emergency service for whichever pimple arrived last. Keep using it after acne clears to help prevent future breakouts.2

What if my skin gets irritated?

Dryness, redness, scaling and burning or stinging can occur during the first two to four weeks. Talk to your doctor if your skin stings, burns or becomes irritated; they can help adjust the frequency or moisturizer. If irritation is severe or does not improve, stop using Differin and consult your doctor before restarting.23

Avoid salicylic acid, glycolic acid and other alpha hydroxy acid products while starting, because they can worsen irritation. Do not combine Differin with another retinoid. If you already use prescription acne treatment, check the combination with your pharmacist rather than adding Differin yourself.123

Do not apply Differin to broken, sunburned or eczema affected skin; wait until it heals. Use SPF 50 sunscreen and protective clothing outdoors, including on cloudy days, and avoid sunbeds. Do not wax the treated area.123

How long should I give it?

Acne can look worse during the first few weeks as previously unseen pimples reach the surface. Early worsening alone is not a reason to stop, but severe irritation needs a different response. Full benefit can take eight to twelve weeks or longer. General acne treatment timelines allow about sixteen weeks for clearing, so judge progress over months rather than individual mornings.36

When should I get medical advice?

Do not start Differin during pregnancy or while trying to conceive without medical advice. Stop treatment if you think you are pregnant and contact your doctor. Check with your doctor before using it while breastfeeding.16

Seek urgent medical help for hives, breathing difficulty or swelling of the face, lips, tongue or throat. See a dermatologist for deep, painful pimples, scarring or no useful improvement after a few months. You can also seek treatment sooner if acne is making you very unhappy.3467