This schedule is general guidance for retinol bought without a prescription; follow your prescriber's directions for a prescription retinoid, the broader family of vitamin A treatments. Choose the lowest strength formula you can find rather than starting with the most intense option.12

How should I apply retinol?

  1. 1Test a little retinol on a small area first. Wait a couple of days and check for redness or itching before adding it to your routine.
  2. 2On a retinol night, wash with a gentle cleanser and pat your skin dry. Do not scrub. If application irritates your skin, try waiting 30 minutes after washing.
  3. 3Follow the package directions. Generally, apply a pea sized amount in a thin layer over your face, keeping it out of your eyes, mouth and nose.
  4. 4Finish with moisturizer. A thin layer of moisturizer before retinol is another option to reduce irritation.
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Keep moisturizer in your morning and evening routine, including nights without retinol. Avoid introducing several new products at once so you are not adding unnecessary opportunities for irritation.45

How do I know when to use retinol more often?

Use tolerance, not a deadline, to decide. Before adding another application, check whether your current schedule is causing redness, itching, burning or peeling. If your skin is comfortable, gradually move toward every other night. Do not jump from occasional use to nightly use just because you have reached a particular week.12

Does retinol need to be used every night?

No, not when you are starting. Alternate nights or once every few days are sensible ways to introduce retinol. Nightly use can be a later step if your skin tolerates it and the product directions allow it. Applying more than the directed amount is not a shortcut: excessive use causes redness and peeling.6

Can I use retinol once a week and still see changes?

How much once weekly use will change your skin, and how long that will take, is uncertain. Regular use matters, but visible improvement is slow: allow about three months for changes from retinol bought without a prescription. Fine lines can take several months to look different. Do not increase frequency simply because the mirror looks unchanged after a few applications.14

Should I pause retinol when my skin starts peeling?

Pause if peeling comes with irritated, red, itchy or burning skin, rather than pushing through or increasing use. Mild dryness can occur, and moisturizer helps with visible scaling. Stop the product and make an appointment with a dermatologist if you develop skin irritation or a rash. Irritation deserves particular attention in darker skin because it can trigger dark marks.256

Who should be careful with retinol?

Do not use retinol during pregnancy or breastfeeding. If you have skin allergies, substantial dryness, or ongoing redness and inflammation, ask a dermatologist whether retinol is appropriate before starting. Sensitive skin can find retinol irritating even at a low frequency.234

You do not need both a retinol serum and a retinol face cream.45

Use retinol at night and sunscreen every morning. Choose broad spectrum SPF 30 or higher, and use shade and protective clothing too. Retinoids can increase sensitivity to sunlight, so sun protection belongs in the routine from the start, not only after you increase frequency.23

Where this answer comes from

  1. 1Retinol: Cream, Serum, What It Is, Benefits, How To Usemy.clevelandclinic.org
  2. 2Retinoid or retinol?aad.org
  3. 3What can treat large facial pores?aad.org
  4. 4Anti-Aging Skin Care: Ingredients and Routinehealth.clevelandclinic.org
  5. 5The Correct Order for Skin Care Productshealth.clevelandclinic.org
  6. 6Follicular disorders. Topical therapy for acnedermnetnz.org