This comparison covers the US Moisturizing Cream formulas, not either brand's lotions or SPF products. Check your package ingredients before buying a replacement, because formulas can change.1

What is actually different?

FeatureCeraVe Moisturizing CreamCetaphil Moisturizing Cream
Target skinNormal to dryDry to very dry
Distinctive ingredientsCeramide NP, AP and EOP; hyaluronic acid; cholesterolNiacinamide; panthenol; sunflower seed oil; sweet almond oil
Shared ingredientsGlycerin, petrolatum and dimethiconeGlycerin, petrolatum and dimethicone
TextureRich, non greasy and fast absorbingRich and non greasy
Sensitive skin featuresFragrance free; allergy tested; National Eczema Association acceptanceFragrance free; hypoallergenic; National Eczema Association acceptance
DirectionsApply liberally as often as needed, day or nightUse daily and as often as needed; massage until absorbed
Price comparisonBrand lists $14.99 without a matched size comparisonNo listed price to compare
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Both are rich creams described as non greasy, so switching brands does not automatically mean switching to something lighter. The matching product names are not helping anyone make this decision.12

Which should you pick?

CeraVe is the straightforward choice if added ceramides are your priority. Ceramides are fats naturally present in the skin's outer layer that help keep moisture in and unwanted substances out. Added ceramides can help replenish that protective layer, and they work well alongside glycerin, hyaluronic acid and dimethicone.3

Cetaphil is worth considering for very dry areas such as hands, feet, elbows and knees. Its panthenol helps hydrate and soothe, while niacinamide helps retain moisture and smooth texture. If you already know you react to one of its ingredients, choose around that reaction rather than the sensitive skin wording.24

For a face that does not need a rich cream, a lighter lotion or gel is generally a better starting point. Both creams carry pore clogging claims, but occlusive moisturizers, which seal moisture in, can aggravate acne. Neither brand name makes a heavy texture the right fit for every face.1245

Compare the price per ounce of the actual jars you are buying rather than declaring either brand cheaper.5

How do you use either cream?

  1. 1Wash gently. Keep baths and showers warm rather than hot, and limit them to five to ten minutes.
  2. 2Pat dry without removing all the water. Apply moisturizer to damp skin within three minutes of washing.
  3. 3Massage the cream gently into the areas that need it. Use either cream daily, morning or evening, and reapply after hand washing or whenever skin feels dry.
  4. 4For daytime protection, apply sunscreen over moisturizer. Choose broad spectrum, water resistant SPF 30 or higher.
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How long should results take?

CeraVe offers long lasting hydration through its MVE delivery system and describes barrier support with continued use. Cetaphil advertises hydration for 48 hours, significant barrier improvement in three days and complete restoration in one week. Keep using moisturizer daily rather than treating the 48 hour claim as an instruction to skip applications.12

What if you have eczema or irritation?

If you have eczema, test a new cream on a quarter sized area inside your arm every day for seven to ten days before wider use. Fragrance free does not mean allergen free, and other ingredients can trigger a flare.57

Stop using a cream if an allergic skin reaction develops. Tell your dermatologist if moisturizer causes burning, stinging or irritation, or if dryness persists despite regular moisturizing. If you already have a prescribed skin treatment plan, continue following it rather than replacing it with a different jar.456

Where this answer comes from

  1. 1Moisturizing Creamcerave.com
  2. 2Intensive Moisturizing Cream for Dry Skincetaphil.com
  3. 3What Do Ceramides Do for Your Skin?health.clevelandclinic.org
  4. 4Emollients and Moisturizers (Moisturisers)dermnetnz.org
  5. 5Choosing the Best Moisturizer for Dry Skinhealth.clevelandclinic.org
  6. 6Dermatologists' top tips for relieving dry skinaad.org
  7. 7How to treat eczema at homeaad.org