Squalane vs glycerin: Which should you use?

What is the difference?

You can use both because attracting water and limiting water loss are complementary jobs. Moisturizers often combine humectants with ingredients that soften skin and reduce evaporation. If your moisturizer already covers both jobs, separate bottles are optional, not a staffing requirement for the bathroom shelf.1

Which should you pick for your skin?

• For dry skin, start with a cream or ointment rather than a lotion. Glycerin is one useful ingredient to look for, but the complete moisturizer matters more than choosing between two ingredient names.
• For skin that remains dry after moisturizer, consider adding squalane oil. It is also an option if you prefer a lightweight oil to the feel of a thicker cream.
• For oily skin, consider a light gel moisturizer. Squalane is an option, but other oils in a squalane product can contribute to blocked pores.
• For combination skin, moisturize the dry areas rather than automatically applying the same amount everywhere.

The better purchase is a moisturizer you are comfortable using regularly, rather than a routine whose main achievement is occupying the sink.4

How do you use them together?

1. 1After washing, gently pat skin dry rather than rubbing it. Leave skin damp for moisturizer.
2. 2Apply your glycerin containing moisturizer. Applying moisturizer promptly after washing helps trap water in the skin.
3. 3If you also use squalane oil, layer it after lighter products. Using the oil after your moisturizer follows the same general layering principle: lighter products first, oil on top.

Moisturizer can be used during the day or at night; the frequency depends on dryness. Slightly dry skin can need only a light moisturizer at night, while more persistent dryness can need repeated applications. Reapply moisturizer when skin feels dry rather than treating the morning application as an all day allowance.13

What should you expect?

The practical benefit is reduced dryness and better support for the skin barrier, the outer layer that helps retain moisture. Moisturizer benefits are greatest during the first six hours after application, so regular use matters. There is no fixed deadline for either ingredient to resolve persistent dryness.1

What if your skin is sensitive?

Choose a fragrance free formula. Fragrances, preservatives and dyes can trigger reactions in sensitive skin, including skin with eczema. With rosacea, the whole formula matters: mild moisturizers can help dryness and irritation, but a familiar moisturizing ingredient alone does not make every product gentle.235

Stop using a product if a new dermatitis rash develops. Tell a dermatologist if moisturizers cause burning, stinging or irritation. Seek care if dryness persists despite moisturizing, or becomes painful, cracked or bleeding; changing from glycerin to squalane is not a substitute for treating an underlying skin condition.134